A Study to Develop Predictive and Prognostic Tools for Optimizing Therapy With Bevacizumab Frontline Cancer Therapy in Participants With HER 2-Negative Aggressive Metastatic Breast Cancer

Inclusion Criteria: * Participants with HER2-negative metastatic breast cancer. Mandatory to have the HER2/estrogen receptor (ER)/progesterone receptor (PR) status * Participant who met criteria for first-line treatment with chemotherapy plus bevacizumab (standard doses) by local, regional or national guidelines or authorities * Participants with measurable disease (RECIST criteria v1.1) or participants with no measurable but assessable disease * Molecular phenotype as triple negative metastatic breast cancer; and ER-positive tumors need to fulfill at least one of the two clinical criteria: metastatic relapse on adjuvant endocrine therapy or progression to at least one prior line of endocrine therapy for advanced disease; or aggressive disease criteria (at least two criteria): taxane based regimen in the (neo) adjuvant setting; metastatic relapse within 2 years from the end of chemotherapy for early breast cancer; liver metastasis; three or more organs with metastatic involvement; symptomatic visceral disease * Eastern Cooperative Oncology Group (ECOG) 0-2 Exclusion Criteria: * Participant has received prior chemotherapy for metastatic disease * Participant requiring major/minor surgery within 3 weeks prior to administration of the first dose of study treatment * Participant has received an investigational therapy within 4 weeks prior to study entry * Participant has known symptomatic brain metastases * Participant with non-measurable or assessable disease: exclusive blastic bone disease; pleural, pericardial or abdominal effusion as only evidence of disease * Participant in chronic daily treatment with corticosteroids (doses greater than \[\>\]10 milligrams per day \[mg/day\] of methylprednisolone or equivalent), except inhaled steroids * Pregnant or breastfeeding participant * Women of childbearing potential who are not using hormonal contraceptives or highly effective birth control during the study * Participant has an active, uncontrolled bacterial, viral, or fungal infection(s) requiring systemic therapy * Participant with significant renal, hematological or liver function alteration according to investigator's criteria * Participant has serious medical risk factors involving any of the major organ systems