Evaluation the Pharmacokinetics, Safety, Tolerability of TK001 in Patients With Neovascular Age-related Macular Degeneration

Inclusion Criteria: * Patients or their legal representative signed informed consent * Aged 45 years to 80 years, male or female * Inpatient/Outpatient with confirmed neovascular AMD * Best corrected VA for the studied eye≤20/100 * With primary or recurrent subfoveal choroidal neovascular (CNV) lesions secondary to neovascular AMD * Blood pressure is stable with SBP\<140 mmHg and DBP\<90 mmHg with or without treatment Exclusion Criteria: * Limitation of eye diseases 1. The studied eye suffered intravitreal blood within two months prior to screening 2. The studied eye suffered structural damage of retinal which involved macular center(such as epiretinal membrane, scars, laser burns, foveal atrophy, dense pigment changes, intensive subfoveal hard exudates) 3. Apparent cataract, aphakia, pseudoexfoliation syndrome, intraocular hemorrhage resulting in decreased vision, rhegmatogenous retinal detachment, macular hole, diabetic retinopathy and diabetic macular disease which need to be treated, choroidal neovascularization (CNV) for any reason except for AMD (such as ocular histoplasmosis, pathologic myopia) 4. Afferent pupillary defect(APD) 5. Refractive media opacity and miosis which effect fundus examination 6. Any eye of patient with active inflammation, such as conjunctivitis, keratitis, scleritis, uveitis and endophthalmitis 7. Choroidal neovascularization (CNV) for other reason, such as diabetic retinopathy, fundus angioid streaks, ocular histoplasmosis, pathologic myopia, trauma * The treatment of the eye 1. The studied eye received topical or grid photocoagulation more than twice or within 3 months before screening 2. The studied eye received any intraocular surgery or laser treatment (such as macular translocation surgery, glaucoma filtering surgery, verteporfin photodynamic therapy, transpupillary thermotherapy, foveal photocoagulation surgery, cataract surgery, vitreous cutting surgery, optic nerve incision operation, YAG posterior capsular incision surgery, sheath incision surgery or filtering surgery) within 3 months before screening 3. Any eye received antiangiogenic drugs (including any anti-VEGF drugs) (such as pegaptanib \[Macugen®\], Aflibercept \[Eylea®\], ranibizumab \[Lucentis ®\], bevacizumab \[Avastin ®\]) within 3 months before baseline visit 4. Any eye received intraocular injection of corticosteroid drugs (such as triamcinolone acetonide), or periocular injection of corticosteroid drugs within 1 months before screening * Systemic diseases,treatment and other conditions 1. With a history of allergy to sodium fluorescein and indocyanine green 2. PLT≤100×109/L, BUN, Cr, thrombin time and prothrombin time beyond the upper limit of the normal range; take anti-platelet aggregation drugs within a month prior to enrollment 3. With surgery within one month prior to enrollment, or with unhealing wound, ulcer, fracture at present 4. Diabetic patients without the control of glucose or accompanied by diabetic retinopathy 5. With a history of myocardial infarction within 6 months before enrolled 6. With activity disseminated intravascular coagulation and a tendency of significant bleeding prior to enrollment 7. Systemic autoimmune disease 8. Any uncontrolled clinical problems (such as severe systemic diseases of mental, neurological, cardiovascular, respiratory and malignancies) 9. Pregnant and lactating women and patients who cannot take contraceptive measures 10. Poor compliance 11. The patients who is considered unsuitable for enrollment by investigator