Alpha Lipoic Acid in Geographic Atrophy

Phase I Inclusion Criteria: * Ages 65-90 * Female participants must be menopausal. Male participants are required to use contraception. * Able to give informed consent * For the study duration (15 days), the subject must remain in the country, remain within 4 hours of travel time (by car or airplane), have access to medical care if needed, and provide contact information so the subject can be reached as needed. Exclusion Criteria: * Blood Pressure greater than 190/100 at the baseline visit * Pulse greater than 100 at the baseline visit * Acute and ongoing systemic infection * History of dementia * Participant has a condition that, in the opinion of the investigator, gives them an unstable medical status. * Participant has geographic atrophy and the investigator believes the participant is a candidate for enrollment into the planned Phase 2 trial for geographic atrophy. Phase II Inclusion Criteria * Age 55-90 * Diagnosis of geographic atrophy from age-related macular degeneration in the study eye. The largest geographic atrophy (GA) lesion must be a minimum of 0.5 optic disk area (DA) (1.25 mm2) and no more than 6 DA in size (15.0 mm2). GA is defined as one or more well-defined, usually more or less circular patches of loss of the retinal pigment epithelium (RPE), typically with exposure of underlying choroidal blood vessels. If the GA is multifocal and the largest lesion is \< 0.5 DA, then there should be at least 3 lesions ≥ 250 microns in greatest linear diameter. * Best-Corrected Visual Acuity (BCVA) between 20/20 and 20/400 in the study eye. * Female participants must be menopausal. Male participants are required to use contraception and cannot donate sperm during study participation. * Presence of hyperfluorescence at the edge of GA on autofluorescence imaging. * Ability to give informed consent. * If a subject has two eligible eyes, then both eyes can be enrolled into the study. * Subject must have mailed back the medication bottle after the 10 day run-in phase, demonstrating that they have taken ≥ 80% of the capsules. Exclusion Criteria * Evidence of ocular disease other than AMD in the study eye that may confound the study outcomes (e.g., History of myopic degeneration, choroidal neovascularization, central serous chorioretinopathy, severe diabetic retinopathy, uveitis, vitelliform dystrophy, or macular edema). * Presence of geographic atrophy that is already touching clearly defined beta peripapillary atrophy or is already touching the optic disc. Beta peripapillary atrophy is defined as peripapillary atrophy in which either the sclera or choroidal vessels are clearly visible. * Any history of intravitreal injection in the study eye for AMD or choroidal neovascularization. However, if a subject develops choroidal neovascularization in the study eye during the study, then the subject will receive the standard of care intravitreal injection treatments per the investigator. The subject will continue to stay in the study. Treatment of choroidal neovascularization (CNV) or other diseases in the non-study eye is at the investigator's discretion. * History of intravitreal injection of any agent (e.g., triamcinolone) other than anti-VEGF (vascular endothelial growth factor) in the study eye within the last four months prior to study enrollment. * History of laser treatment (including photodynamic therapy) to the macula for the study eye. * History of intraocular surgery within 90 days. for the study eye. * History of anterior segment laser (laser peripheral iridotomy, laser to trabecular meshwork, YAG capsulotomy) within 90 days for the study eye. * Media opacity (corneal scar, cataract) that would prevent adequate fundus imaging for the study eye. * Any history of participation in another therapeutic clinical trial for GA. * Participation currently or within the past 30 days in another therapeutic clinical trial in which a systemic or ocular study medication is received by the subject. * GA in the study eye due to a cause other than AMD * History of prior use of ALA. * AREDS (Age Related Eye Disease Study) vitamins taken at standard doses are not considered an exclusion criterion. Taking a standard multivitamin is not considered an exclusion criterion. However, the multivitamin should not contain alpha lipoic acid (also known as thioctic acid). * Taking antioxidant supplements other than a standard multivitamin (such as bilberry, vitamin C that is not part of a multivitamin or taken at higher doses than the AREDS formula, vitamin E that is not part of a multivitamin or taken at higher doses than the AREDS formula, or other similar antioxidants) within one month of enrollment is an exclusion criteria; these patients should discontinue the antioxidant supplement one month before enrollment in order to participate. Taking a supplement that has antioxidant potential that is recommended by a physician as standard-of-care medical management is not an exclusion criterion.). * Participant has a condition that, in the opinion of the investigator, would preclude participation in the study for 18 months (e.g., unstable medical status including blood pressure and glycemic control, unstable psychiatric history, moving and not able to return for all planned study visits). * History of a formal diagnosis of dementia by a neurologist. * History of gastric ulcer within the past 5 years. * History of irritable bowel syndrome within the past 5 years.