Clinical Trial to Evaluate Safety and Efficacy of Hyperthermic Intra-peritoneal Chemotherapy (HIPEC) With Mitomycin C Used During Surgery for Treatment of Locally Advanced Colorectal Carcinoma

Inclusion Criteria: 1. Male and female patients between the ages of 18 and 75 years; 2. Adenocarcinoma of the colon, sigma and colon-sigma joint which represent cT4a/b in line with The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual; 3. Lymph node involvement: N0, the presence of N1/2 according to the 7th edition of the AJCC is allowed, provided that they can be resectable; 4. Metastatic extent: M0; 5. Karnofsky index \>70 or Performance status ≤2; 6. Informed consent properly completed. Exclusion Criteria: 1. Presence of metastases (M1), in case of liver or peritoneal metastases at the time of surgery, the patient will be excluded from the trial and treated according to their new stage. 2. Presence of unresectability criteria; 3. Urgent intervention due to obstruction or perforation if there is tumor removal, prior interventions will be accepted as referrals without primary tumor removal or drainage of collections prior to scheduled surgery. 4. Extraperitoneal rectal cáncer (avoiding alterations for neoadyuvance); 5. Coexistence of another malignant neoplastic disease (synchronous tumors of the colon and upper rectum are accepted as long as the stage is equal to or less than the treated tumor). 6. Severely altered liver, kidney and cardiovascular function; 7. Intolerance to treatment; 8. Administration of chemotherapy before the trial (use of neoadyuvance is discarded); 9. Pregnant or breastfeeding women.