The aims of this study were to investigate how intake of tailor-made salmon affected bone biomarkers, nutritional status, as well as body composition and bone mineral density. The 122 healthy postmenopausal women included in this 12 weeks intervention study were randomized into four groups: three salmon groups (with three different vitamin D3/vitamin K1 combinations) and one tablet group (vitamin D and Calcium).
Suboptimal vitamin D status is common among humans, and might have a negative impact on bone health. Fatty fish, including Atlantic salmon, is an important dietary vitamin D source. However, due to a considerable change in fish feed composition, the contribution of vitamin D from salmon fillet has been reduced. The aims were to investigate how intake of tailor-made salmon affected bone biomarkers, nutritional status (vitamin D, omega-3), as well as body composition and bone mineral density (BMD). The 122 healthy postmenopausal women (median 55 years) included in this 12 weeks intervention study were randomized into four groups: three salmon groups (150 grams/two times/week) and one tablet group (800IU vitamin D and 1000 mg Calcium/day). The salmon groups also received calcium supplements (1000 mg/d). The salmon had three different vitamin D3/vitamin K1 combinations: high D3 + high K1, low D3 + high K1, or high D3 + low K1.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
122
The aims were to investigate how intake of tailor-made salmon with high levels of vitamin D3 and K1 affected bone biomarkers, nutritional status (vitamin D, omega-3), as well as body composition and bone mineral density.
The aims were to investigate how intake of tailor-made salmon with low levels of vitamin D3 and high K1 affected bone biomarkers, nutritional status (vitamin D, omega-3), as well as body composition and bone mineral density.
NIFES
Bergen, Norway
Bone-specific alkaline phosphatase
Serum (µg/l)
Time frame: 3 months
Osteocalcin
Serum (ng/ml)
Time frame: 3 months
Undercarboxylated osteocalcin (GLU)
Serum (ng/ml)
Time frame: 3 months
Carboxylated osteocalcine (GLA)
Serum (ng/ml)
Time frame: 3 months
GLU/GLA-ratio
Ratio of undercarboxylated osteocalcin and carboxylated osteocalcine
Time frame: 3 months
N-telopeptides/creatinine
Urinary (mmol/l)
Time frame: 3 months
Deoxypyridinoline/creatinine
Urinary (mmol/l)
Time frame: 3 months
25-hyroxyvitamin D
Serum 25(OH)D (nmol/L)
Time frame: 3 months
Eicosapentaenoic acids
Fatty acids composition of total red blood cells
Time frame: 3 months
Docosahexaenoic acids
Fatty acids composition of total red blood cells
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The aims were to investigate how intake of tailor-made salmon with high levels of vitamin D3 and low K1 affected bone biomarkers, nutritional status (vitamin D, omega-3), as well as body composition and bone mineral density.
The aims were to investigate how supplement with vitamin D and Calcium affected bone biomarkers, nutritional status (vitamin D, omega-3), as well as body composition and bone mineral density.
Time frame: 3 months
Omega-3 index
The content of Eicosapentaenoic acids and Docosahexaenoic acids in red blood cell membranes expressed as percent of total fatty acids.
Time frame: 3 months
Body composition
Total body soft tissue composition (fat mass and lean mass) measurements were performed using dual-energy X-ray absorptiometry (DXA) on a stationary fan beam densitometer.
Time frame: 3 months
Bone mineral density
The total body bone mineral density (BMD) measurements were performed using dual-energy X-ray absorptiometry (DXA) on a stationary fan beam densitometer.
Time frame: 3 months