Visfatin Levels Before and After Periodontal Treatment

Bulent Ecevit University45 enrolled

Overview

The purpose of this study was to evaluate visfatin levels in different stages of periodontal diseases and health, moreover the effect of non-surgical periodontal therapy on visfatin levels in Gingival Crevicular Fluid (GCF) and Serum.

Total of 45 patients were divided into three groups based on their clinical and radiographical examination. Group 1 chronic periodontitis (n: 15), group 2 plaque induced gingivitis (n: 15) and group 3 Periodontal health (n: 15). GCF and serum samples were collected before treatment and 1, 3, 6 months after treatment and were assayed using enzyme linked immunosorbent assay kit.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Periodontal Diseases

Interventions

Non-surgical Periodontal Treatment.PROCEDURE

Non-surgical periodontal therapy is an anti-infective therapy which includes both mechanical and chemotherapeutic approaches to minimize or eliminate microbial biofilm, the primary etiology of gingivitis and periodontitis

Eligibility

Sex: ALLMin age: 25 YearsMax age: 49 YearsHealthy volunteers:

Medical Language ↔ Plain English

Group 1 Inclusion Criteria: * GI\>1, PPD≥5mm, CAL≥5mm with alveolar bone loss radiographically. * Systematically healthy patients Group 2 Inclusion Criteria: * No alveolar bone and attachment loss * Inflammation signs such as redness, edema and increased BOP levels, * GI≥2, PPD≤3mm, CAL≤3mm. * Systematically healthy patients Group 3 Inclusion Criteria: * No bone and attachment loss, * GI=0, PPD≤3mm, CAL≤3mm * Systematically healthy patients Exclusion Criteria for all groups: * Aggressive Periodontitis, * Oral pathologies, * Patients with any other systemic diseases, * Pregnant women and those in the lactation period, * Patients with smoking habit and taking medication * Patients received periodontal therapy in last 6 months

Outcomes

Primary Outcomes

Visfatin levels: Change after periodontal treatment both in serum and GCF

Time frame: baseline, 1, 3 and 6 months

Data from ClinicalTrials.gov

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