PI3Kβ Selective Inhibitor With Paclitaxel, Advanced Gastric Adenocarcinoma

Inclusion criteria: 1. histologically or cytologically confirmed diagnosis of advanced gastric adenocarcinoma 2. Has a PTEN-deficient tumor as documented from archival or fresh (from biopsy) tumor tissue or has shown genomic alterations in PI3K pathway genes (PIK3CB, PI3KR1, PTEN, etc.) as assessed in a local laboratory. 3. Has had no prior taxane exposure (preferred) or at least 6 months since last taxane exposure. 4. Eastern Cooperative Oncology Group performance status of 0 or 1 5. measurable or evaluable disease as determined by RECIST 1.1. 6. Is able to swallow and retain orally administered medication 7. adequate baseline organ function Exclusion criteria 1. prior treatment with any AKT, mammalian target of rapamycin (mTOR) inhibitors or PI3K pathway inhibitors 2. Has any unresolved Grade 2 (per CTCAE v4.0) toxicity from previous anti-cancer therapy at the time of enrollment such as neuropathy, except alopecia or Grade 2 anemia (if hemoglobin is ≥9.0 g/dL) 3. Has CNS metastases 4. Has a QTc interval \>450 msec or QTc \>480 msec for subjects with bundle branch block (BBB) 5. Has a known immediate or delayed hypersensitivity reaction or idiosyncrasy to drugs chemically related to GSK2636771 or hypersensitivity to drug formulated in polyoxyl 35 castor oil, NF such as paclitaxel.