A Single-Center, Exploratory Study to Analyze the Dynamics of Skin Microflora Following Exposure to Surfactants

Kimberly-Clark Corporation24 enrolled

Overview

The purpose of this study is to understand the changes in skin microflora, skin barrier function, and skin biochemical constituents in response to direct contact with model surfactants used in personal care articles. The results from this study will provide insights into the complex interaction between the skin microbiome and the epidermis after exposure to surfactants.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Dermatitis

Interventions

PEG-40 Hydrogenated Castor Oil (Tagat CH40, Evonik) 1.5%OTHER

Lauryl glucoside (Plantacare® 1200UP, BASF) 1.5%OTHER

Sorbitan palmitate (SPANTM 40 (powder), Croda) 1.5%OTHER

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy Subjects with Fitzpatrick Skin Types I, II or III Exclusion Criteria: * Subjects with visible skin disease, tattoos, skin condition, or abnormal skin color

Locations (1)

Reliance Clinical Testing Service

Irving, Texas, United States

Outcomes

Primary Outcomes

Type of microbes present on skin after exposure to various surfactants

Microbes will be identified by metagenomic sequencing

Time frame: 4 days

Amount of microbes present on skin after exposure to various surfactants

Time frame: 4 days

Data from ClinicalTrials.gov

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