This study is designed to evaluate the feasibility and safety of partial breast irradiation for low risk DCIS after breast-conserving surgery.
Randomized clinical trials have demonstrated that the recurrence of DCIS is low and most of the recurrence occurs around the tumor bed. Besides, cosmetic outcomes are reported better in partial breast irradiation group compared to whole breast irradiation group. However, whether or not partial breast irradiation is safety in DCIS is still unknown. The purpose of this study is to evaluate the feasibility and safety of partial breast irradiation for low risk DCIS after breast-conserving surgery.
Study Type
OBSERVATIONAL
Enrollment
828
The prescription dose is 40.5Gy in 15 fractions in 3 weeks.
Fudan University Shanghai Cancer Center
Shanghai, Shanghai Municipality, China
RECRUITINGipsilateral breast tumor recurrence
Time frame: 5 years
occurrence of contralateral breast tumor after PBI
Time frame: 5 years
Disease free survival
Time frame: 5 years
Overall survival
Time frame: 5 years
radiation-induced toxicity of breast assessed by CTCAE v4.0
Time frame: baseline, 3 months, 6 months, and every half year to 5 years
Complications
Time frame: baseline，1，2，3，4，5 years
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