This study was designed to compare the effects of gabapentin and ramosetron on PONV in patients undergoing laparoscopic gynecologic surgery.
Postoperative nausea and vomiting (PONV) in the postanesthesia care unit is a common occurrence after general anesthesia. And laparoscopic gynecological surgery is associated with a high incidence of PONV. Several antiemetic agents such as dopaminergic, histaminic and 5-HT3 antagonist (including ondansetron, ramosetron, granisetron) have been used to prevent PONV. Gabapentin, anti-convulsant, has been shown to decrease PONV, as well as chemotherapy induced nausea and vomiting in recent studies, although the exact mechanism against PONV is not known. The purpose of this study was to compare the efficacy of gabapentin and ramosetron in preventing PONV in patients undergoing laparoscopic gynecological surgery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
120
oral gabapentin 300 mg 1 hour before induction of anesthesia
ramosetron 0.3 mg iv at end of surgery
oral gabapentin 300 mg 1 hour before induction of anesthesia and ramosetron 0.3 mg iv at end of surgery
Hallym University Sacred Heart Hospital
Anyang-si, Gyeonggi-do, South Korea
Incidence of postoperative nausea and vomiting
The incidence of postoperative nausea and vomiting will be assessed during 48 hours after surgery
Time frame: 48 hours postoperative
Severity of nausea
The severity of nausea will be assessed using verbal rating scales (VRS 11-points scales: 0=no nausea to 10=nausea as bad as it could be)
Time frame: 48 hours postoperative
pain score
The pain score will be assessed using verbal rating scales (VRS 11-points scales: 0=none to 10=most severe)
Time frame: 48 hours postoperative
sedation score
The sedation score will be assessed using verbal rating scales (VRS 11-points scales:0=none to 10=most severe)
Time frame: 48 hours postoperative
patient's overall satisfaction score
The patient's overall satisfaction score will be assessed using 5 point scales (5=very satisfied, 4=somewhat satisfied, 3=neither satisfied nor dissatisfied, 2=somewhat dissatisfied, 1=very dissatisfied)
Time frame: 48 hours postoperative
side effects
The side effects such as somnolence, dizziness, headache, tremor, diplopia and nystagmus will be assessed and treated
Time frame: 48 hours postoperative
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