Vericiguat Drug-drug Interaction With Nitroglycerin in Stable Coronary Artery Disease Patients

Inclusion Criteria: Patients with stable CAD defined by * coronary artery stenosis in any of the 3 main coronary vessels \> 50% documented by coronary angiography within last 36 months or history of myocardial infarction * Age: 30 to 80 years * Body mass index (BMI): above/equal 18.0 and below/equal 36.0 kg / m² * Female subjects must be of non-childbearing potential Exclusion Criteria: * Intervention e.g. revascularization by percutaneous coronary intervention (PCI) and/or coronary artery bypass graft (CABG) during the last 3 months * Progressive angina with symptoms of worsening of angina within the \< 3 months * History of recent (\< 6 months prior to the first screening examination) myocardial infarction or unstable angina * Symptomatic carotid stenosis, or transient ischemic attack or stroke within 3 months prior or patients with stroke at more than 3 months prior with significant residual neurologic involvement * Insulin dependent diabetes mellitus * Clinically relevant cardiac ischemia * Clinical significant persistent ischemia * Atrial fibrillation, pacemaker, defibrillator, atrial ventricular (AV)-block II and III * Systolic blood pressure below 110 or above 160 mmHg * Diastolic blood pressure above 100 mmHg * Heart rate below 50 or above 100 beats / min * Estimated glomerular filtration rate \< 30 mL/min/1.73m2