Laparoscopic Roux-en-Y Gastric Bypass (LRYGB) is considered the weight loss procedure of choice for patients suffering of gastro-esophageal reflux (GER). However, long term instrumental evaluations of GER after LRYGB are not available. The aim of this study is to evaluate the long-term effects of laparoscopic Roux-en-Y Gastric Bypass (LRYGB) on gastro-esophageal function.
Consecutive morbidly obese patients selected for LRYGB were included in a prospective study. The investigators performed clinical evaluation with GERD-HRQoL and GIS questionnaire, upper endoscopy, esophageal manometry and 24h-impedance pH monitoring (24h-MII-pH) preoperatively and at 12 and 60 months after surgery. Patients were divided into 2 groups according to the presence of GER at preoperative 24h-MII-pH.
Study Type
OBSERVATIONAL
Enrollment
86
Number of weakly acidic reflux
number of weakly acidic reflux at 24 hour pH impedance monitoring
Time frame: preoperatively, 12 and 60 months after LRYGB
GERD-HRQoL clinical score
Standard and previous validated questionnaire was employed in the study to assess gastroesophageal function and quality of life
Time frame: preoperatively, 12 and 60 months after LRYGB
Lower esophageal sphincter pressure
Esophageal manometry measures lower esophageal sphincter pressure
Time frame: preoperatively, 12 and 60 months after LRYGB
Amplitude of esophageal peristaltic waves
Esophageal manometry evaluates amplitude of esophageal peristalsis
Time frame: preoperatively, 12 and 60 months after LRYGB
Grade of esophagitis
Upper endoscopy is performed to assess the presence of esophagitis
Time frame: preoperatively, 12 and 60 months after LRYGB
Number of acidic reflux
number of acidic reflux at 24 hour pH impedance monitoring
Time frame: preoperatively, 12 and 60 months after LRYGB
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