Helium Oxygen Mixture in the Treatment of Meconium Aspiration Syndrome

N/ACompletedNCT02620891

Ma Juan60 enrolled

Overview

Helium-oxygen mixture(heliox) was suggested to be beneficial in meconium aspiration syndrome in previous studies，but the evidence was limited．The aim of the study was to assess the effectiveness of synchronize intermittent mandatory ventilation (SIMV) with heliox (70% helium and 30% oxygen) on length of ventilation(LoV) and cardiopulmonary protection in meconium aspiration syndrome.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Neonatal Meconium Aspiration

Interventions

helium oxygen mixtureDEVICE

Eligibility

Sex: ALLMin age: 37 WeeksMax age: 40 WeeksHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Subject has the diagnosis of neonatal meconium aspiration syndrome * Subject has Synchronous instruction ventilation Exclusion Criteria: * History of congenital or hereditary disease

Locations (1)

Department of Pediatrics, Daping Hospital, Third Military Medical University

Chongqing, Chongqing Municipality, China

Outcomes

Primary Outcomes

blood gas analysis

Time detection after treatment

Time frame: 2 hour

blood gas analysis

Time frame: 6 hour

blood gas analysis

Time frame: 12 hour

blood gas analysis

Time frame: 24 hour

blood gas analysis

Time frame: 48 hour

Secondary Outcomes

Inflammatory response index (IL-6,IL-8, TNF-a,CRP)

Time frame: 0 hour

Inflammatory response index (IL-6,IL-8, TNF-a,CRP)

Time frame: 6 hour

Data from ClinicalTrials.gov

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