Cerebral Microembolism in the Critically Ill With Acute Kidney Injury

Insel Gruppe AG, University Hospital Bern66 enrolled

Overview

The primary objective of this study is to investigate the impact of continuous renal replacement therapy and intermittent renal replacement therapy on microbubble / cerebral microemboli generation in a cohort of critically ill patients with dialysis-dependent acute kidney injury.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Cerebral Embolism

Interventions

Renal replacement therapyDEVICE

Patients receive renal replacement therapy according to institutional standards

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * \> 18 yrs. * Signed IC Exclusion Criteria: * Heart disease (PFO, ASD, VSD, severe valvular disease) * Atrial fibrillation * Cerebrovascular pathology * Missing temporal bone window * Allergy to plastic contained in the investigative device (transcranial Doppler) * Chronic kidney disease * Pregnancy * Participation in another study

Locations (1)

University Hospital Bern

Bern, Switzerland

Outcomes

Primary Outcomes

Cerebral Microembolic Load detected by Transcranial Doppler Ultrasound

Time frame: During hemodialysis therapy

Data from ClinicalTrials.gov

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