Bilateral Comparison of Treatment of Facial Actinic Keratoses Using Microneedling and Photodynamic Therapy With Aminolevulinic Acid and Blue Light Versus Photodynamic Therapy With Aminolevulinic Acid and Blue Light Using Two Incubation Times

Inclusion Criteria: * Subject is male or non-pregnant female over the age of 18 years. Females must be post-menopausal, surgically sterile or using a medically acceptable form of birth control, with a negative urine pregnancy test at the Baseline visit. * Subject has provided written and verbal informed consent. * Subject has four (4) or more AK lesions on each side of the face. * Subject is willing to comply with study instructions and return to the clinic for required visits. * Subject has Fitzpatrick skin type I-IV Exclusion Criteria: * Subject is pregnant, lactating, or is planning to become pregnant during the study. * Subject has a history of cutaneous photosensitization, porphyria, hypersensitivity to porphyrins or photodermatosis or any condition with associated immunosuppression (e.g. HIV, systemic malignancy, etc.). * Subject has any skin pathology or condition that could interfere with the evaluation of the test product or requires the use of interfering topical or systemic therapy. * Subject has any condition, which, in the investigator's opinion, would make it unsafe for the subject to participate in this research study. * Subject has Fitzpatrick skin type V - VI. * Subject is currently enrolled in an investigational drug or device study. * Subject has received an investigational drug or been treated with an investigational device within 30 days prior to the initiation of treatment (baseline). * Subject is unable to communicate or cooperate with the investigator due to language problems, poor mental development, or impaired cerebral function. * Subject may be unreliable for the study including subjects who engage in excessive alcohol intake or drug abuse, or subjects who are unable to return for scheduled follow-up visits. * Subject has a known sensitivity to one or more of the vehicle components (ethyl alcohol, isopropyl alcohol, laureth 4, polyethylene glycol). * Subject has the need to be exposed to artificial tanning devices or excessive sunlight during the trial. * Subject has used any of the following topical preparations on the area(s) to be treated * Keratolytics including urea (greater than 5%), alpha hydroxyacids \[e.g. glycolic acid, lactic acid, etc. greater than 5%\], salicylic acid (greater than 2%) within 2 days of initiation of treatment. * Retinoids, including tazarotene, adapalene, tretinoin, retinol, within 4 weeks of the initiation of treatment. * Cryotherapy, dicofenac or other treatments for AK within 8 weeks of initiation of treatment * Microdermabrasion, laser ablative treatments or chemical peels within 8 weeks of the initiation of treatment. * 5-FU, imiquimod or ALA-PDT within 6 months of initiation of treatment. * Subject has used any of the following systemic medications: * Immuno-suppressants including steroids, chemotherapy, etc. within 3 months of the initiation of treatment * Retinoid therapy within 6 months of the initiation of treatment.