Investigators performed a randomized controlled trial of 62 patients undergoing elective abdominal operations. The treatment group was provided a liquid protein supplement and instructed to take a dose three times daily for the first 20 postoperative days. Investigators followed patients for six months and compared wound healing and changes in weight and laboratory values.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
62
Prostat AWC- patients received protein supplementation after surgery
Placebo- Patients did not take any protein supplementation after surgery
Change in weight
Mean preoperative weight compared to mean postoperative weight at each follow-up appointment. Weight recorded in pounds, subsequent measurements at each postoperative point were normalized to the preoperative weight and reported as a relative percentage of the preoperative weight.
Time frame: Preoperative, and then postoperative at 1-2 weeks, 3 weeks, 1 month, 2 months, 3 months, 6 months
Wound healing
Overall wound healing was documented on a scale of 0-2 (0 for unhealed, 1 for partially healed, 2 for completely healed). A wound was considered partially healed if there was any portion of the wound which had epidermal edges that were not in direct contact.
Time frame: Preoperative, and then postoperative at 1-2 weeks, 3 weeks, 1 month, 2 months, 3 months, 6 months
Change in white blood cell count (1x10 3/ uL)
Change in white blood cell count relative to preoperative white blood cell count, calculated as absolute change
Time frame: Preoperative, and then postoperative at 1-2 weeks, 3 weeks, 1 month, 2 months, 3 months, 6 months
Change in total protein (g/ dL)
Change in total protein at each follow-up point relative to preoperative total protein, calculated as absolute change
Time frame: Preoperative, and then postoperative at 1-2 weeks, 3 weeks, 1 month, 2 months, 3 months, 6 months
Change in albumin (g/ dL)
Change in albumin at each follow-up point relative to preoperative albumin, calculated as absolute change
Time frame: Preoperative, and then postoperative at 1-2 weeks, 3 weeks, 1 month, 2 months, 3 months, 6 months
Change in prealbumin (mg/ dL)
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Change in prealbumin at each follow-up point relative to preoperative prealbumin, calculated as absolute change
Time frame: Preoperative, and then postoperative at 1-2 weeks, 3 weeks, 1 month, 2 months, 3 months, 6 months