Lactobacillus Plantarum 3547 Effects Over Inflammatory and Immunologic Markers

Inclusion Criteria: * Men and women from 45 to 65 years old; * Body Mass Index (BMI) ≥ 18,5 and \< 40 kg/m2 * Signed informed consent. * Adequate cultural level and understanding for the clinical trial. * Free of infections at baseline Exclusion Criteria: * Individuals with severe diseases (hepatic, kidney, cancer…); * Individuals with diagnosed metabolic syndrome, diabetes and/or hyperthyroidism; * Individuals with chronic intestinal pathologies (Gastritis, Colitis, Irritable Bowel Syndrome, Pseudomembranous Colitis, Crohn's disease…); * Individuals with dementia, mental disease or low cognitive function; * Individuals with autoimmune diseases and/or under treatment with corticosteroids and/or immunosuppressants; * Individuals with major surgeries during the last month or gastrointestinal surgery in the last 3 months; * Individuals treated with oral antibiotics during two weeks prior to the beginning of the study; * Individuals undergoing dietary restriction and/or pharmacological treatment for the decrease of body weight 2 months prior to the beginning of the study; * Individuals who intend to quit smoking during the next 20 weeks; * Women that consume oral contraceptive; * Pregnant women or breastfeeding; * Individuals with intensive physical activity (\> 2 hours, more than 3 times per week); * Individuals that consume antioxidant supplement, drugs, ω-3 supplements, vitamins, minerals, prebiotics or/and probiotics during the 2 weeks prior to the beginning of the study and that will not eliminate their consumption during the study; * Individuals with regular consumption (\> 3 servings per week) of fermented foods (yogurt, actimel, kefir, blue cheese…) and/or use of other prebiotics and not to accept suppress their consumption during the study; * Individuals with increased alcohol consumption \>30g/day (equivalent to 300 ml of wine, about 3 beers or a cup (75 ml) of whiskey , brandy , anise, etc); * Individuals with regular use of laxatives (\> 2 a week) and (Laxbene, Miralax, Dulco - Lax, etc.) and does not accept suppress its consumption during the study period.