The study will be conducted in participants with type1 diabetes on insulin injection therapy to investigate how the body processes a test formulation of insulin lispro and the effect of the test formulation on blood sugar levels. Side effects and tolerability will be documented. The study will be conducted in two parts (Part A and Part B) to achieve its objectives. Participants are expected to enroll in both parts.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Administered subcutaneously (SC)
(Part A) Pharmacokinetics (PK): Area Under the Concentration Curve (AUC) of Insulin Lispro
(Part A) PK: AUC of Insulin Lispro
Time frame: Time 0 to 5 hours post dose for each treatment on Day 1
(Part B) PK: AUC of Insulin Lispro
(Part B) PK: AUC of Insulin Lispro
Time frame: Time 0 to 5 hours post dose on Day 1 and Day 14 of study treatment
(Part A) Pharmacodynamics (PD): AUC of Glucose Following a Meal
(Part A) PD: AUC of Glucose Following a Meal
Time frame: Time 0 to 5 hours post meal for each treatment on Day 1
(Part B) PD: AUC of Glucose Following a Meal
(Part B) PD: AUC of Glucose Following a Meal
Time frame: Time 0 to 5 hours post meal on Day1 and Day14 of study treatment
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