Serum Bupivacaine Concentration Levels After Injection of Liposomal Bupivacaine Into the Knee

University of Utah40 enrolled

Overview

Serum levels of bupivacaine over time after peri-articular injection of a mixture of liposomal bupivacaine and plain bupivacaine during total knee arthroplasty.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Anesthesia, Local

Interventions

liposomal bupivacaine/plain bupivacaine peri-articular injectionDRUG

Injection of a mixture of liposomal and plain bupivacaine around the knee during total knee arthroplasty.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Adults of at least 18 years of age having a primary, unilateral total knee arthroplasty with a surgical plan to have an intra-articular injection of a mixture of 266 mg of Exparel, 125 mg of bupivacaine, 1:300,000 epinephrine, and 0.9% saline to make a total volume of 100 ml. Exclusion Criteria: * Known hepatic dysfunction or renal insufficiency (creatinine \> 1.5 mg/dL); * allergy to the study medications; * pregnancy; * incarceration; * inability to communicate with the investigators; * morbid obesity (body mass index \> 40 kg/m2).

Locations (1)

Uutah

Salt Lake City, Utah, United States

Outcomes

Primary Outcomes

Serum Bupivacaine levels

Time frame: 5 minutes to 24 hours after injection

Data from ClinicalTrials.gov

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