Exercise-induced High-sensitivity Troponin Levels as a Predictor for Obstructive Coronary Artery Disease

Universitaire Ziekenhuizen KU Leuven150 enrolled

Overview

1. To compare hs-TnT levels after a cardiac stress test in patients with vs. patients without CAD 2. To assess the level of post-exercise hs-TnT predicting CAD (using ROC-analysis) 3. To determine the sensitivity, specificity and accuracy of this exercise-induced hsTopT level in predicting CAD, either alone or in relation to traditional patient-related and exercise test-related metrics

Study Type

OBSERVATIONAL

Enrollment

150

Conditions

Coronary Artery Disease

Eligibility

Sex: ALLMin age: 18 YearsMax age: 99 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients with suspected CAD, planned for diagnostic coronary angiogram 2. Patients with previous revascularization, suspected of recurrent ischemia Exclusion Criteria: 1. Congestive cardiomyopathy with LV EF \< 35% 2. Renal failure with eGFR \< 30 ml/min 3. Known structural or severe valvular heart disease 4. Prior CABG 5. Previous ACS \< 6 weeks 6. Known incomplete revascularization after previous PCI 7. Unstable angina or ACS (defined as unstable anginal symptoms + ECG changes or hs-TnT \> 0.053 ng/L)

Locations (1)

UZLeuven

Leuven, Belgium

RECRUITING

Outcomes

Primary Outcomes

Presence of coronary artery stenosis more than 50%

Time frame: 24 hours

Central Contacts

Dries De Cock, MD

CONTACT

003216341519 dries.decock@uzleuven.be

Nick Hiltrop, MD

CONTACT

003216344235 nick.hiltrop@uzleuven.be

Data from ClinicalTrials.gov

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