The aim of the present study is: 1. to verify whether the delineation of the tumour bed, based on the combination of the visible postoperative changes and the position of the surgical clips on a CT scan in treatment position acquired 1 week before the start of the radiotherapy (RT), provides an accurate localisation of the boost volume compared to the localisation of the tumour on a pre-operative CT-scan. 2. to document the changes that occur in the tumour bed as seen on a CT scan as a function of the delay between surgery and radiotherapy. 3. to determine the ideal number and the positioning of the clips needed to reproduce the best treatment volume for the boost. 4. to propose new guidelines for tumour bed definition and delineation based on the study findings.
Start of the study: february 2012
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
25
Beside the standard post-operative CT-scan, an extra pre-operative CT-scan is performed.
UZ Leuven
Leuven, Belgium
the interobserver variability (IOV) (%) of the delineated Clinical Target Volume (CTV) boost (cm3) with and without the fusion of the pre-operative CT-scan.
Time frame: 2 years
the volume of the delineated CTVboost (cm3) with and without the fusion of the pre-operative CT-scan.
Time frame: 2 years
the correlation of the Cavity Visibility Scale (CVS) to volume changes and IOV
Time frame: 2 Years
the volume changes over time (in case of adjuvant chemotherapy)
Time frame: 2 years
the usefulness of the surgical clips assessed by the 6 observers.
Time frame: 2 years
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