The main purpose of this project is to determine the impact of atrial fibrillation interventions (catheter ablation and exercise training) on circulating BDNF concentrations in patients with atrial fibrillation. It also seeks to determine if there is a relation between circulating BDNF concentrations and mental health (depression severity, quality of life and symptoms) among those undergoing interventions for atrial fibrillation catheter ablation or exercise training.
The main purpose of this project is to determine the impact of atrial fibrillation interventions (catheter ablation and exercise training) on circulating BDNF concentrations in patients with atrial fibrillation. It also seeks to determine if there is a relation between circulating BDNF concentrations and mental health (depression severity, quality of life and symptoms) among those undergoing interventions for atrial fibrillation catheter ablation or exercise training. Using a pre-post study design, the investigators will explore interventions in two subsets of patients at the opposite end of the atrial fibrillation clinical spectrum. Arm 1: patients with paroxysmal atrial fibrillation will undergo catheter ablation (n=100). Arm 2: patients with permanent or persistent atrial fibrillation will perform exercise training 2 times weekly for 12 weeks (n=100). Total sample size will be 200 participants. All measurements will be performed at baseline and follow-up.
Study Type
OBSERVATIONAL
Enrollment
200
Subjects undergoing catheter ablation for the first time for atrial fibrillation as part of their regular care (regardless of involvement in this study).
Subjects participating in supervised exercise classes for up to 60 minutes in length 2 times/week as part of their involvement in another study (NCT02602457).
University of Ottawa Heart Institute
Ottawa, Ontario, Canada
RECRUITINGChanges in circulating BDNF concentrations measured by blood samples collected from subjects with atrial fibrillation
Changes in circulating BDNF concentrations measured by blood samples collected from subjects with atrial fibrillation approximately 3 months post catheter ablation or following the 12 week exercise training intervention.
Time frame: approximately 3 months post catheter ablation or following the 12 week exercise training intervention period
Changes in subjects' symptoms measured by the patient diary for symptoms
Changes in subjects' symptoms measured by the patient diary for symptoms approximately 3 months post catheter ablation or following the 12 week exercise training intervention period.
Time frame: approximately 3 months post catheter ablation or following the 12 week exercise training intervention period
Changes in depression severity measured using the Beck Depression Inventory II (BDI-II)
Changes in depression severity measured using the Beck Depression Inventory II (BDI-II) approximately 3 months after catheter ablation or following the 12 week exercise training intervention period.
Time frame: approximately 3 months post catheter ablation or following the 12 week exercise training intervention period
Changes in general quality of life as measured by the Short Form Health Survey 36 (SF-36)
Changes in general quality of life as measured by the Short Form Health Survey 36 (SF-36) approximately 3 months after catheter ablation or following the 12 week exercise training intervention period.
Time frame: approximately 3 months post catheter ablation or following the 12 week exercise training intervention period
Changes in disease specific quality of life measured by the University of Toronto Atrial Fibrillation Severity Scale (AFSS)
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Changes in disease specific quality of life measured by the University of Toronto Atrial Fibrillation Severity Scale (AFSS) approximately 3 months after catheter ablation or following the 12 week exercise training intervention period.
Time frame: approximately 3 months post catheter ablation or following the 12 week exercise training intervention period