Interbody Spacers With map3® Cellular Allogeneic Bone Graft in Anterior or Lateral Lumbar Interbody Fusion

Inclusion Criteria: * is at least 18 - 75 years of age and skeletally mature * must have symptomatic spondylosis, spondylolisthesis grade I or II, or degenerative disc disease (DDD) at one level from L2-S1 requiring a fusion * must be a candidate to use an allograft spacer * must be a candidate for bilateral pedicle screw placement * must have completed a minimum of six weeks (+/- two to four weeks of bracing) of unsuccessful conservative, non-operative care * must have discogenic back pain with or without leg pain DDD must be confirmed by MRI or CT scans followed by discography (if necessary) * must score at least 40 % on the Oswestry Disability Index * must score 4 or more on a 10 cm Visual Analog Scale for back pain or leg pain * must be able to comply with the protocol's follow-up schedule * must understand and sign the informed consent documenT Exclusion Criteria: * symptomatic at more than one level * previous fusion surgery at any lumbar level with or without instrumentation. * any other bone grafting product other than study product and local autograft bone. e.g. rhBMP2, (recombinant human bone morphogenetic protein 2). * patients requiring any other interbody fusion device other than an allograft spacer (Bigfoot™, Crossfuse® Advantage). e.g. no PEEK IBF * more than 50% spondylolisthesis (Myerding grade III or more) * lumbar scoliosis greater than 11 degrees * osteoporosis\* (T-score of -2.5 or lower), osteomalacia, Paget's disease or --metabolic bone disease. * spinal tumors * active arachnoiditis * fractures of the epiphyseal plate or fractures for which stabilization of the fracture is not possible. * impaired calcium metabolism * active infection or surgical site infection * rheumatoid arthritis or other autoimmune disease that affects bone healing (at the surgeon's discretion) * chronic steroid use except for chronic inhalers (used steroids for one month within the last 6 months) or any medical condition that requires treatment with drugs known to interfere with bone healing * use of glucocorticoids \> 10 mg/day * systemic disease such as AIDS, HIV, hepatitis (active), tuberculosis * morbid obesity defined as body mass index (BMI) \>45 or a weight more than 100 lbs. over ideal body weight * uncontrolled diabetes documented with an Hbg A1C \>9 or insulin dependent diabetics * smokers unless approved by Sponsor, including electronic cigarettes and vaporizers * within the past two (2) years, psychosocial disorders that would preclude accurate evaluation or has a history of substance abuse any history or active cancer * pregnancy, or interested in becoming pregnant while participating in the study * participation in another investigational study within 30 days