180 Degree vs. 360 Degree Selective Laser Trabeculoplasty as Initial Therapy for Glaucoma

Temple University76 enrolled

Overview

Selective laser trabeculoplasty (SLT) is a well-recognized way to lower eye pressure in treatment of glaucoma. This treatment is performed for 180 degrees or 360 degrees, and studies at academic centers have shown mixed results when comparing the success rates of 180 degrees or 360 degrees. Both protocols are now typically done by comprehensive ophthalmologists. However, there is no data that compares success rates of 180 degrees and 360 degrees in the community setting.

This study is designed as a prospective evaluation of the two treatment algorithms for SLT by measuring intraocular pressure (IOP) after treatment. The hypothesis is that 360 degrees of SLT will produce a greater reduction in IOP than 180 degrees of SLT at 3 months follow up.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Open Angle Glaucoma Ocular Hypertension Glaucoma, Open Angle, Pseudo-exfoliative

Interventions

Selective Laser TrabeculoplastyPROCEDURE

The procedure uses light energy provided by a neodymium (Nd):Yttrium Aluminum Garnet (YAG) laser that is directed into the iridocorneal angle via a goniolens viewed through a standard slit lamp.

Neodymium:Yttrium Aluminum Garnet (YAG) laserDEVICE

The procedure uses a 400 μm spot size of light energy provided by a low-energy, Q-switched, frequency-doubled (532 nm) neodymium (Nd):Yttrium Aluminum Garnet (YAG) laser with a short pulse duration of 3 nanoseconds that is directed into the iridocorneal angle via a goniolens viewed through a standard slit lamp.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients who have been diagnosed with open-angle glaucoma including ocular hypertension, pseudoexfoliation and pigment dispersion syndrome * greater than 18 years of age * initial intraocular pressure (IOP) of ≥ 21 mmHg Exclusion Criteria: * prior medical or laser therapy to lower IOP * previous incisional glaucoma surgery before the study period

Locations (2)

Brandywine Eye Center

Wilmington, Delaware, United States

Levin Luminais Chronister Eye Associates

Thorndale, Pennsylvania, United States

Outcomes

Primary Outcomes

Intraocular Pressure (IOP) Measured by Tonometry in Millimeters of Mercury at Three Months of Follow-up

Intraocular pressure (IOP) measured by tonometry in millimeters of mercury at three months of follow-up

Time frame: 3 months

Secondary Outcomes

Intraocular Pressure (IOP) Measured by Tonometry in Millimeters of Mercury at 1 Year of Follow-up

Intraocular pressure (IOP) measured by tonometry in millimeters of mercury at 1 year of follow-up

Time frame: 1 year

Intraocular Pressure (IOP) Measured by Tonometry in Millimeters of Mercury at Time at Which Additional Glaucoma Therapy is Required

Intraocular pressure (IOP) measured by tonometry in millimeters of mercury at time at which additional glaucoma therapy is required

Time frame: within 1 year of study intervention

Intraocular Pressure (IOP) Measured by Tonometry in Millimeters of Mercury at Last Follow-up

Intraocular pressure (IOP) measured by tonometry in millimeters of mercury at last follow-up

Time frame: within 1 year of study intervention