Analgesic Effects of Midazolam in Human Volunteers

Inclusion Criteria: * male and female volunteers * 18-40 years old * healthy * body mass index between 5th and 85th percentile * Caucasian * non smoker or moderate smoker (\<10 cigarettes per day) * able to understand, write, and read German Exclusion Criteria: * acute or chronic pain condition (except for mild day-to-day pain on \<5 days/month) * previous (up to 5 days preceding the study) or current medications prescription or over-the-counter, especially analgesics * symptoms of a clinically relevant illness in the 2 weeks before the first study day * hypertension * any known psychiatric condition * abuse of alcoholic beverages, drug abuse * known positive human immunodeficiency virus status * any known medical condition which may interact with study medication, study objectives, or compliance of subject with study tasks * participation in a clinical trial in the 4 weeks preceding the study * known allergy against Midazolam * known allergy against Fentanyl * pregnancy or breast-feeding * unable or unwilling to give informed consent * unable or unwilling to follow investigator's instructions * unable or unwilling to comply with study protocol