To Determine Blood Concentrations of Ibuprofen and Caffeine in a Tablet Against Ibuprofen Alone From Another Tablet

Inclusion criteria: * Healthy males and females, 18 to 50 years (inclusive) at time of screening. * Body Mass Index (BMI) between 18.5 and 29.9 kg/m2 (inclusive). * Body mass not less than 50 kg. * Medical history, vital signs, physical examination, standard 12-lead electrocardiogram (ECG) and laboratory investigations must be clinically acceptable or within laboratory reference ranges for the relevant laboratory tests, unless the PI considers the deviation to be irrelevant for the purpose of the study. * Non-smokers and mild or moderate smokers (\<= 10 cigarettes or pipes per day). Further inclusion criteria apply Exclusion criteria: * Evidence of psychiatric disorder, antagonistic personality, poor motivation, emotional or intellectual problems likely to limit the validity of consent to participate in the study or limit the ability to comply with protocol requirements. * Current alcohol use \> 21 units of alcohol per week for males and \> 14 units of alcohol per week for females. One unit is equal to beer \[200 mL/10 ounces\], wine \[100 mL/4 ounces\], or distilled spirits \[25 mL/1 ounce\]) per day * Regular exposure to substances of abuse (other than alcohol) within the past year. * Use of any medication, prescribed or over-the-counter or herbal remedies, within 2 weeks before the first administration of IMP except if this will not affect the outcome of the study in the opinion of the PI. In this study the concomitant use of hormonal contraceptives is allowed. * Participation in another study with an experimental drug, where the last administration of the previous IMP was within 8 weeks (or within 5 elimination half-lives for chemical entities or 2 elimination half-lives for anti-bodies or insulin), whichever is the longer) before administration of IMP in this study, at the discretion of the PI. * Treatment within the previous 3 months before the first administration of IMP with any drug with a well-defined potential for adversely affecting a major organ or system. * History of hypersensitivity or allergy (angioedema or urticaria) to the IMP or its excipients or any related medication (Aspirin or any other NSAID). * Diagnosis of hypotension made during the screening period. * Diagnosis of hypertension made during the screening period or current diagnosis of hypertension. * Resting pulse of \> 100 beats per minute or \< 40 beats per minute during the screening period, either supine or standing. * Renal impairment. * Positive urine screen for drugs of abuse. In case of a positive result the urine screen for drugs of abuse may be repeated once at the discretion of the PI. Further exclusion criteria apply