A Study to Evaluate Pain, Tolerability, Safety, and Usability of a Single Self-administered Etrolizumab by Auto-injector in Healthy Participants

Inclusion Criteria: * Males or females, between 18 and 65 years of age, inclusive * Within body mass index (BMI) range 18.0 to 32.0 kilograms per square meter (kg/m\^2), inclusive * In good health, determined by no clinically significant findings from medical history, 12-lead electrocardiograms (ECGs), and vital signs * Females will be non-pregnant, non-lactating, and either postmenopausal (at least 1 year of non therapy induced amenorrhea), surgically sterile (absence of ovaries and/or uterus) for at least 90 days, or agree to remain abstinent or use a highly effective method of contraception for at least 24 weeks after the single dose of study drug * Males will either be sterile or agree to remain abstinent or use a highly effective method of contraception for at least 24 weeks after the single dose of study drug. Male participants will refrain from sperm donation from Check-in (Day -1) until 24 weeks following study drug administration Exclusion Criteria: * Participation in any other investigational study drug or biological agent trial (including investigational vaccines) in which receipt of an investigational study drug occurred within 30 days or 5 half-lives or receipt of a biologic agent occurred within 90 days or 5 half-lives, whichever is longer, prior to Check-in (Day -1) and during the entire study * Any prior treatment with etrolizumab or other anti integrin agents (including natalizumab, vedolizumab, and efalizumab) * Any prior exposure to immunosuppressive agents (e.g., methotrexate, azathoprine, mercaptopurine) * Use of IV steroids within 30 days prior to Screening; * Chronic nonsteroidal anti inflammatory drug (NSAID) * Use of any prescription medications/products within 14 days prior to Check in (Day -1) * History of demyelinating disease * Neurological conditions or diseases * History of cancer * History of alcoholism or drug addiction within 1 year prior to Check-in (Day -1) * History of active or latent tuberculosis (TB), regardless of treatment history * History of recurrent opportunistic infections, severe disseminated viral infections (e.g., herpes), or any serious opportunistic infection within the last 6 months * Positive for human immunodeficiency virus (HIV) antibody * Any current or recent signs or symptoms of infection * Inability to sense pain (e.g., peripheral neuropathy) and have a history of or have been diagnosed with a chronic pain syndrome