The Relationship Between ALDH2 and Aortic Dissection

N/AUnknownNCT02630212

Qilu Hospital of Shandong University400 enrolled

Overview

The purpose of this study is to evaluate the impact of ALDH2 Glu504Lys polymorphism on aortic dissection.

Study Type

OBSERVATIONAL

Enrollment

400

Conditions

Aortic Dissection

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Chinese Han people diagnosed with aortic dissection in Qilu Hospital Exclusion Criteria: * Aortic dissection based on trauma, connective tissue diseases and pregnancy * Patients with tumor * Patients with no written consensus

Locations (1)

Qilu Hospital of Shandong University

Jinan, Shandong, China

RECRUITING

Outcomes

Primary Outcomes

Number of patients with different ALDH2 genotype

DNA was extracted from venous blood;genomic DNA underwent PCR amplification; finally, PCR products were purified and directly sequenced by Invitrogen Corp or Biosune Corp.Then ALDH2 genotype was distinguished depend on a G-to-A missense mutation on exon 12 of ALDH2 gene.

Time frame: 1-30 days after samples collected

Secondary Outcomes

Concentration of inflammatory factors in blood and aortic specimen

Concentration of 4-HNE、MMP-2、MMP-9 detected by elisa kit、IHC or western blot in relevant specimen.

Time frame: 1-30 days after samples collected

ALDH2 activity

Activity of ALDH2 was detected in blood and aortic specimen depend on its reducibility of NAD+

Time frame: 1-30 days after samples collected

Data from ClinicalTrials.gov

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