Chronopharmacology of Valsartan in Normotensive Subjects

Inclusion Criteria: 1. At least 18 years old and not more than 45 healthy male volunteers 2. Actual weight no more than ± 30% from ideal body weight based on sex, height, and body frame 3. Who had passed all the screening parameters including physical examination, laboratory tests. 4. Who had to be able to communicate effectively with study personnel, be literate, and able to give consent. 5. diurnal active subjects with eight hour night sleep. 6. free of any drug exposure known to interfere with the pharmacokinetics/pharmacodynamics or assay of valsartan for at least 10 days prior to the study Exclusion Criteria: 1. Treatment with any known enzyme-inducing/inhibiting agents within 30 days prior to the start of the study and throughout the study. 2. Susceptibility to allergic reactions to valsartan. 3. Any prior surgery of the gastrointestinal tract that may interfere with drug absorption. 4. Gastrointestinal diseases. 5. Renal diseases. 6. Cardiovascular diseases. 7. Pancreatic disease including diabetes. 8. Hepatic diseases. 9. Hematological disease or pulmonary disease 10. Abnormal laboratory values. 11. Subjects who have donated blood or who have been involved in multiple dosing study requiring a large volume of blood (more than 500 ml) to be drawn within 6 weeks preceding the start of the study. 12. Nocturnal active subjects