The Effect of Succinylated Gelatin on the Blood Viscosity and Oxygen Delivery

First Affiliated Hospital, Sun Yat-Sen University12 enrolled

Overview

The study is to investigate the effect of succinylated gelatin on the blood viscosity and oxygen delivery in patients during surgeries, so as to have a better understanding of the safety in the use of succinylated gelatin for surgical patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

SINGLE

Enrollment

Conditions

Blood Viscosity

Interventions

Ringer's lactate solutionDRUG

Succinylated gelatinDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients between the ages of 18 years and 60 years * ASA physical status I and II * surgical procedures requiring general anesthesia with continuous CVP and arterial pressure monitoring Exclusion Criteria: * Patients younger than 16 y or older than 60 y * Body Mass Index (BMI) \<18 or \>30 * Allergy to any of the drugs used * Severe cardiovascular dysfunction * Patient refusal

Locations (1)

The First Affiliated Hospital of Sun Yat-Sen University

Guangzhou, Guangdong, China

RECRUITING

Outcomes

Primary Outcomes

The patient's arterial blood viscosity (mpa.s) as tested by viscometer

Time frame: up to 5 months (after the infusion of succinylated gelatin )

Secondary Outcomes

The patient's oxygen delivery index (DO2I) as calculated by Vigileo

Time frame: up to 5 months (after the infusion of succinylated gelatin )

Central Contacts

Xia Feng, MD. Ph.D.

CONTACT

13688877856 fengxia@mail.sysu.edu.cn

Data from ClinicalTrials.gov

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