Airway Pressure During Nasal High Flow and CPAP in Neonates

Research Center of Maternal and Child Health Protection, Armenia10 enrolled

Overview

Nasal High Flow (NHF) and CPAP are established forms of respiratory support in neonates and often produce similar clinical outcomes. The aim of the study was to investigate airway pressure during NHF and CPAP in neonates.

Methods: A physiological study which measured pressure intra-nasally with micro (750 µm) pressure probes (Millar, USA) in 10 (5M / 5F) healthy newborns with mean gestation age 37.18 (SD 1.29) wk and mean birth weight of 2414 (SD 503.13) g. NHF was applied at 8 L/min (AIRVO 2) through smaller (OPT 314) and larger (OPT 316) Optiflow nasal cannula; CPAP 5 cmH20 was produced by a Bubble CPAP system and nasal mask interface at constant flow 8 L/min (Fisher \& Paykel Healthcare, NZ). Values are expressed in cmH20 as means and standard deviations (SD).

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Respiratory Insufficiency

Interventions

NHF small cannulaDEVICE

NHF 8 l/min by Airvo 2 by small cannula

NHF big cannulaDEVICE

NHF 8 l/min by Airvo 2 by large cannula

CPAPDEVICE

Nsal CPAP 5cm H2o by face mask

Eligibility

Sex: ALLMin age: 1 DayMax age: 3 DaysHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy term newborns Exclusion Criteria: * Newborns with any medical problems after birth * Absent of parents consents

Locations (2)

Neonatal Intensive Care Unit, Research Centre of Maternal and Child Health

Yerevan, Armenia

RCMCHP

Yerevan, Armenia

Outcomes

Primary Outcomes

Upper airway pressure generated by NHF compared to CPAP

Pressure in upper airways

Time frame: Up to 1 hour

Data from ClinicalTrials.gov

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