Comparison of Brain Perfusion in Rhythm Control and Rate Control of Persistent Atrial Fibrillation

Yonsei University200 enrolled

Overview

Atrial fibrillation (AF) is associated with impaired cognitive function (CogF) and/or dementia, but it is unclear whether rhythm control of AF improves CogF or brain perfusion. The hypothesis is rhythm control of AF improves CogF by increasing brain perfusion with hemodynamic amelioration compared to AF state. We will randomize the patients with persistent AF to rhythm control group and rate control group, and check baseline and 3rd month cognitive function (K-MOCA score) and brain perfusion CT. K-MOCA score and brain perfusion CT findings will be compared between rhythm control group and rate control group of persistent AF.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

200

Conditions

Persistent Atrial Fibrillation

Interventions

Eligibility

Sex: ALLMin age: 20 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with persistent Atrial fibrillation (20\~80 years old) * LA diameter \< 55mm * patients possible to anticoagulation and anti arrhythmic drug Exclusion Criteria: * Structural cardiac disease * Contraindication to brain perfusion CT * Catheter ablation history for AF, Cardiac surgery * active internal bleeding * Impossible to anticoagulation or antiarrhythmic drug * valvular AF ((MA\> GII, Mechanical valve, Mitral valve replacement) * LVEF \< 30% * With severe medical disease * Expected survival \< 1 year * Severe alcoholics, drug addiction

Outcomes

Primary Outcomes

K-MOCA(Korean version of Montreal Cognitive Assessment)

Time frame: 12 months after the enrollment

Brain perfusion CT