Effect of Loading of Midazolam or Dexmedetomidine on Hemodynamics

Konkuk University Medical Center

Overview

Loading dose of dexmedetomidine is related hemodynamic instability such as bradycardia and hypertension.

The investigators hypothesized substitution of loading of dexmedetomidine for midazolam could reduce hemodynamic instability during spinal anesthesia for knee arthroscopy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Conditions

Knee Injuries

Interventions

dexmedetomidine groupDRUG

intravenous loading of dexmedetomidine for 1 mcg/kg

midazolam groupDRUG

intravenous loading of midazolam for 0.1 mg/kg

Eligibility

Sex: ALLMin age: 20 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients who were planned to undergo knee arthroscopy under spinal anesthesia Exclusion Criteria: * age \< 20 years * underlying heart, liver or kidney disease * hypersensitivity to midazolam or dexmedetomidine

Locations (1)

Konkuk University Medical Center

Seoul, South Korea

Outcomes

Primary Outcomes

change of heart rate

Time frame: from 1 minute before anesthesia to 1 hr after anesthesia

Secondary Outcomes

change of bispectral index

Time frame: from 1 minute before anesthesia to 1 hr after anesthesia

Data from ClinicalTrials.gov

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