A Study of ALKS 3831 in Adults With Acute Exacerbation of Schizophrenia (the ENLIGHTEN-1 Study)

Inclusion Criteria: * Has a body mass index (BMI) of 18.0 - 40.0 kg/m\^2 * Meets criteria for the diagnosis of schizophrenia * Resides in a stable living situation when not hospitalized * Is willing and able to provide government-issued identification * Additional criteria may apply Exclusion Criteria: * Has had a psychiatric hospitalization for more than 30 days during the 90 days before screening * Subject initiated first antipsychotic treatment within the past 12 months, or \<1 year has elapsed since the initial onset of active-phase of schizophrenia symptoms * Subject poses a current suicide risk * Subject has a history of treatment resistance * Subject has a history of poor or inadequate response to treatment with olanzapine * Subject requires or has had electroconvulsive therapy (ECT) treatment in the 2-month period prior to screening * Subject has a diagnosis of moderate or severe alcohol or drug use disorder * Subject has a positive urine drug screen for opioids, amphetamine/methamphetamine, phencyclidine, or cocaine at screening * Additional criteria may apply