A Multicenter Randomized Control Trial in Children With Moderate to Severe Atopic Dermatitis to Assess the Benefit of a Nurse-led One-to-one Education Program in Addition to Standard Care Compared to Standard Care Alone on the Long Term Control of Disease Severity at 6 Months

Inclusion Criteria: * Patient with AD, defined according to the criteria of the United Kingdom Working Party : AD should be diagnosed when a child has an itchy skin condition plus three or more of the following: Protocol EDU DA RC15\_0035 Version n°4 du 15/09/16 Page 28 sur 44 CONFIDENTIAL Visible flexural dermatitis involving the skin creases, such as the bends of the elbows or behind the knees (or visible dermatitis on the cheeks and/or extensor areas in children aged under 10 years) Personal history of flexural dermatitis (or dermatitis on the cheeks and/or extensor areas in children under 10 years) Personal history of dry skin in the last 12 months Personal history of asthma or allergic rhinitis (or history of atopic disease in a firstdegree relative of children aged under 4 years) * Onset of signs and symptoms under the age of 2 years (this criterion should not be used in children aged less than 4 years). Patient aged at least 3 months and less than 18 years. * SCORAD 20 (moderate to severe AD) * Patient who received treatment an anti-inflammatory topical treatment (topical corticosteroid or topical tacrolimus) * Informed consent of parents * Agreement of the child when appropriate * Patient affiliated to French social security system Exclusion Criteria: * Patient does not meet the criteria of AD * SCORAD \< 20 * Patient aged 18 years or more * Patient treated with oral corticosteroids currently or systemic immunosuppressant 2 months prior to the eligibility assessment * Patients with primary immunodeficiency diseases. * Consent not given * Patient not affiliated to French social security system * Patient with intercurrent disease, may be excluded if the investigator believes participation in the trial is not in the best interest of the patient * Personal decision of the child or their parents not to be included * Child and / or parents lack the mental capacity to give informed consent * Child / Parents do not have a sufficient command of the French language for understanding TPE program. * Patient or parent who has already received structured TPE for AD.