The PRE-AR project is a longitudinal observational study. The primary objective is the assessment of lung function parameters in late preterm preschool children.
The PRE-AR project is a longitudinal observational study. The primary objective is the assessment of lung function parameters in late preterm preschool children. Pulmonary function tests will be performed.
Study Type
OBSERVATIONAL
Enrollment
152
Lung Function Assessment
Institute of Biomedicine and Molecular Immunology, IBIM
Palermo, Italy
Forced oscillation technique
Longitudinal assessment of forced oscillation technique (FOT)
Time frame: Baseline, 24 months, and 48 months
Spirometry
Longitudinal assessment of spirometry
Time frame: Baseline, 24 months, and 48 months
Interrupter resistance
Longitudinal assessment of interrupter resistance (RINT)
Time frame: Baseline, 24 months, and 48 months
Nasal nitric oxide
Longitudinal assessment of nasal nitric oxide (nNO)
Time frame: Baseline, 24 months, and 48 months
Atopy
Positivity to at least one aeroallergen
Time frame: Baseline
Nasal brushing
Assessment of alterations and inflammatory changes in the nasal mucosa
Time frame: Baseline
Saliva sample
Phenotypic characterization through the collection of saliva samples
Time frame: 24 months, and 48 months
Urine analysis
Endotypic characterization through urine proteomic analysis
Time frame: Baseline, 24 months, and 48 months
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