The purpose of this study is to address the effect of consuming 4g of soluble fibre beta-glucan at breakfast on satiety and food intake.
Satiation and satiety are part of the body's complex appetite control system that ultimately play a role in limiting energy intake. Satiation is referred to as the process that leads to the termination of eating, which may be accompanied by feelings of satisfaction. Satiety is the feeling of fullness that persists after eating, with the potential to suppress further energy intake until hunger returns. There is evidence to suggest that increasing gastro-intestinal viscosity improves appetite control and reduces subsequent food intake. Beta-glucan is a soluble fibre proposed to behave this way. In this double-blinded, randomized, crossover trial, subjective appetite sensations will be measured and blood will be collected at specific time points during the two arms in order to determine hormonal responses. Ad libitum food intake will be recorded. Food diaries will be used to measure dietary intakes.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
36
Isocaloric breakfast without added beta-glucans
Queen Margaret University, Edinburgh
Musselburgh, East Lothain, United Kingdom
Variation in energy intakes
Ad libitum food intake (kilocalories) will be determined during an 'all you can' eat buffet lunch. Food intakes will be measured over 5 days; 3 days prior to the study day, on the day of the study and the day after.
Time frame: 1 day
Variation in the feelings of appetite
Measure of the satiating effect for each breakfast with Visual Analog Scale (Area Under the Curve) over time for subjective appetite parameters
Time frame: -30, 0, 15, 30, 45, 60, 75, 90, 105, 120, 135, 150 minutes
Variation in GLP-1
Measure plasma total glucagon-like peptide 1 (GLP-1) area under the curve (AUC) over time.
Time frame: 0, 30, 60, 90 minutes
Variation in insulin
Measure plasma insulin (pg/mL) area under the curve (AUC) over time.
Time frame: 0, 30, 60, 90 minutes
Variation in glucose
Measure blood glucose (mmol/L) area under the curve (AUC) over time.
Time frame: 0, 30, 60, 90, 120 minutes
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