In children, only a few studies have compared different modes of propofol infusion during a total intravenous anesthesia (TIVA) with propofol and remifentanil. The aim of this study is to compare Bispectral Index (BIS) profiles (percentage of time spent at adequate BIS values) between four modes of propofol infusion: titration of the infusion rate on clinical signs (TIVA0), titration of the infusion rate on the BIS (TIVABIS), target controlled infusion (TCI) guided by the BIS either with the Kataria model (TCI KBIS) or the Schnider model (TCI SBIS). Methods: Children will be prospectively randomized into the 4 groups. In the TIVA0 group the anesthesiologist is blinded to the BIS. In each group, the percentage of time with adequate BIS values (45-55), the bias and imprecision will be calculated.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
66
Target controlled infusion using schnider model for propofol
Target controlled infusion using Kataria model for propofol
Total intravenous anesthesia without use of a pharmokinetic model
Maintaining a bispectral index between 45 and 55
Remifentanil at discretion of the anesthesiologist
Departement d'anesthesie Hopital Armand Trousseau
Paris, France
Percentage of time spent at adequate BIS values
Time frame: from the beginning to the end of the anesthesia
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