The Expression of Matrix Metalloproteinase 13, Tissue Inhibitor of Metalloproteinases 3, and Calcium-sensing Receptor in Human Trabecular Meshwork

Inclusion Criteria: * intraocular pressure greater than 22 mmHg with two or more medications * wide anterior chamber angle * glaucomatous optic neuropathy (Glaucomatous optic nerve damage was defined as cup-to-disc ratio higher than 0.7 or focal loss of the nerve fiber layer (notch) associated with a consistent glaucomatous visual field defect * visual field loss consistent with optic nerve damage and visual fields were performed by using standard automated perimetry Exclusion Criteria: * the presence of any secondary form of glaucoma including exfoliation syndrome or a history of ocular trauma, etc