This study compared Ulcer healing rate of Ilaprazole 20mg or Rabeprazole 20mg in the patients undergone Endoscopic Submucosal Dissection for Gastric Adenoma or Early Gastric Cancer and investigated Prevention of gastrointestinal bleeding.
This study is a Multicenter, Randomized, Parallel and Prospective study to compare Ulcer healing rate of Ilaprazole 20mg or Rabeprazole 20mg in the patients undergone Endoscopic Submucosal Dissection for Gastric Adenoma or Early Gastric Cancer and to investigate Prevention of gastrointestinal bleeding. Participants are defined as persons who underwent a Endoscopic Submucosal Dissection for Gastric Adenoma or Early Gastric Cancer. For 8 weeks, Participants treated as Ilaprazole 20mg or Rabeprazole 20mg once a day. After treatment, The ulcer healing rate was evaluated by Endoscopy at 4, 8 weeks.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
176
Ilaprazole 10mg 2tablets once a day(1 times / day), before breakfast
Rabeprazole 20mg 1tablets once a day(1 times / day), before breakfast
HALLYM UNIVERSITY MEDICAL CENTER, Chuncheon Sacred Heart Hospital
Chuncheon, Gangwon-do, South Korea
The Ulcer healing rate after endoscopic submucosal dissection
Time frame: participants will be followed at 8 weeks
The rate of Ulcer size reduction as assessed by measurements of ulcer size change.
The rate of Ulcer size reduction(Δ) : \[(Initial ulcer size) - (Ulcer size at 8 weeks)\] / (Initial ulcer size)
Time frame: at 8 weeks after treatment
The quality of ulcer healing as evaluated by the observation of investigator at tracking endoscopy.
Apply 0.15% Indigo carmine to scarring of the ulcer and Describe the pattern of the scar as flat, nodular or intermediate at tracking endoscopy.
Time frame: at 8 weeks after treatment
The evaluation of symptom score as assessed by the Korean Gastrointestinal Symptom Rating Scale questionnaire.
The Korean Gastrointestinal Symptom Rating Scale questionnaire measured the patient's symptom degree.
Time frame: at 8 weeks after treatment
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