Ketorol Gel in Gonarthrosis and Low Back Pain

General inclusion criteria: 1. Patients of both sexes in the age group from 20 to 70 years, who have signed informed consent for participation in the study. 2. Understanding of spoken or written communication, adequate for being able to follow procedures of the Protocol and fill in documents related to the study. 3. For women: patients who are not pregnant, not breast-feeding. The female patients must be in either the post-climacteric period or surgically sterile, or for the entire period of the study use contraceptive methods with a reliability level of higher than 90%. Methods of contraception with higher than 90% level of reliability of common use include cervical caps with spermicide, diaphragms with spermicide, condoms, oral contraceptives. Criteria of inclusion in the group "gonarthrosis": 1. Patients of both sexes in the age group from 40 to 70 years. 2. Roentgenologically confirmed gonarthrosis (presence of roentgenological symptoms of osteophytes and stenosis of joint space). 3. Intensity of pain in the knee joint as per visual analogue scale (VAS), when still: ≥40 mm, during movement: ≥ 50 mm. 4. Presence of one of the under mentioned combinations of criteria: 1. Pain in the knee joint during the last one month, accompanied by crepitation in active movement of the joint, morning stiffness up to 30 min, age - 38 years and older. 2. Pain in the knee joint during the last one month, accompanied by crepitation in active movement of the joint, morning stiffness up to 30 min., bone enlargements in the joint area. 3. Pain in knee joint during the last one month in the absence of crepitation, bone enlargements in joint area Criteria of inclusion in the group "low backpain" : 5. Patients of both sexes in the age group of 20 to 65 years with acute pain syndrome in the lower part of the back (less than 12 weeks). 6. Intensity of pain in the back as per VAS when still ≥40 mm, during movement ≥ 50 mm. Exclusion Criteria: * 1\. Feedback on Informed Consent Form signed by the patient for participation in the Study. 2\. Continuation of participation in the study is in conflict with the patient's interests. 3\. Occurrence of a serious adverse event in the patient, the relation of which to the administration of the drug under study is classified definite, probable or possible. 4\. Patient needs additional treatment which may affect the parameters of efficacy under study. 5\. Violations of the protocol, which in the opinion of the investigator or sponsor of the study, are significant for evaluation of results of the clinical trial. 6\. Discontinuation of the study by the sponsor. 7. Discontinuation of the study by the investigator. 8. Discontinuation of the study by the regulatory bodies.