Biochemical Alterations of Stored Erythrocyte Membranes

Medical University of Vienna36 enrolled

Overview

The investigators will define procoagulant properties of packed red blood cells and investigate whether packed red blood cells from certain donor populations are prone to induce procoagulant states.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Coagulation

Interventions

protein expression pattern of packed red blood cellsOTHER

the proteome of packed red blood cells will be assessed at predefined time points

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * group 1: healthy female volunteers 18-35 y.o. * group 2: healthy male volunteers 18-35 y.o. * group 3: healthy female volunteers 36-60 y.o. * group 4: healthy male volunteers 36-60 y.o. * group 5: female volunteers 36-60 y.o., BMI 26-45 * group 6: male volunteers 36-60 y.o., BMI 26-45 Exclusion Criteria: * age below 18 years * age above 60 years

Locations (1)

Medical University of Vienna

Vienna, Austria

Outcomes

Primary Outcomes

protein expression pattern

Time frame: week 0

protein expression pattern

Time frame: week 2

protein expression pattern

Time frame: week 4

protein expression pattern

Time frame: week 6

Data from ClinicalTrials.gov

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