The purpose of this study is to determine whether the chinese medicine Jian Pi Yi Shen Hua Tan granules is effective in the treatment of cognitive impairment after acute cerebral infarction .
The present study is designed to observe the symptoms,syndrome characteristics and neuropsychological changes of patients with cognitive dysfunction after Acute Cerebral Infarction, as well as study the patterns of syndrome evolution and neuropsychological characteristics, in order to provide evidences for the early-stage identification, diagnosis, intervention and treatment based on syndrome differentiation. To assess the effectiveness of applying early-stage prevention on patients with cognitive impairment after Acute Cerebral Infarction through the use of traditional Chinese medicine--Jian Pi Yi Shen Hua Tan granules, explore the pathogenesis and therapeutic efficacy mechanism, evaluate the effectiveness of early-stage prevention and provide alternative solutions for preventing or delaying dementia.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
300
Jianpi Yishen Huatan Granules contain Herba cistanche,Fructus Alpinia Oxyphyllae,Rhodiola rosea, Polygala tenuifolia willd and Coptis chinensis.Jianpi Yishen Huatan Granules dissolved in water of 100 ml ,po, bid of each 90-days cycle. Number of treatment cycles: one
Treat with the placebo which contain 5% of prescription of Jian Pi Yi Shen Hua Tan Granules and 95% dextrin.The placebo dissolved in water of 100 ml ,po, bid of each 90-days cycle. Number of cycles: one
Department of Neurology,Dongfang Hospital
Beijing, Beijing Municipality, China
Shunyi Hospital of Traditional Chinese Medicine
Beijing, Beijing Municipality, China
Chongqing Hospital of Traditional Chinese Medicine
Chongqing, Chongqing Municipality, China
Jiangmen Wuyi Hospital of Traditional Chinese Medicine
Jiangmen, Guangdong, China
mini-mental state examination
Using mini-mental state examination to examine the patients' cognitive function
Time frame: 90 days
Montreal Cognitive Assessment scale
Using Montreal Cognitive Assessment scale to examine the patients' cognitive function
Time frame: 90 days
Stroop test
Using Stroop test to examine executive function and attention
Time frame: 90 days
Numerical sequence test(DS-S)
Using Numerical sequence test(DS-S) to examine memeory
Time frame: 90 days
Digital color connection test (CCT)
Using Numerical sequence test(DS-S) to examine executive function and attention
Time frame: 90 days
Verbal memory test(HVLT)
Using Verbal memory test(HVLT) to examine verbal memory
Time frame: 90 days
national institute of health stroke scale
Using national institute of health stroke scale to examine the neurologic function impairment
Time frame: 90 days
modified Rankin scale
Using modified Rankin scale to examine the recovery of neurologic function
Time frame: 90 days
Activity of Daily Living Scale
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the Affiliated Hospital to Changchun University of Chinese Medicine
Changchun, Jilin, China
Using Activity of Daily Living Scale to examine daily living ability
Time frame: 90 days
scores of Chinese medicine symptoms
Using the scores of Chinese medicine symptoms to examine the Chinese medicine syndrom
Time frame: 90 days