Longterm Followup of Patients With Rheumatoid Arthritis Treated With Methotrexate

N/ACompletedNCT02641977

Ruhr University of Bochum271 enrolled

Overview

Longterm followup of patients with rheumatoid arthritis 30 years after starting a baseline treatment with Methotrexate.

Objective. 30-year follow-up of rheumatoid arthritis (RA) patients treated with methotrexate (MTX) in the 1980s to analyze the association of the degree of response to MTX with long-term mortality. Methods. In this observational cohort study, 271 RA patients who had started treatment with MTX between 1980 and 1987 were included (mean age 58 years, mean disease duration 8.5 years). One year after baseline, the treatment response to MTX was evaluated. Responders were defined as patients with at least 20% improvement. Thereafter, assessments were performed at 10 and 18 years after baseline. This re-evaluation was done to provide the data after 30 years of follow-up. Standardized mortality ratios (SMR) are calculated, Cox regression and logistic regression are performed.

Study Type

OBSERVATIONAL

Enrollment

271

Conditions

External Causes of Morbidity and Mortality

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * rheumatoid arthritis * treatment with methotrexate * active disease Exclusion Criteria: * low disease activity * previous treatment with methotrexate

Locations (1)

Internistische und rheumatologische Praxis Gladbeck

Gladbeck, Germany

Outcomes

Primary Outcomes

mortality

Time frame: 30 years

Data from ClinicalTrials.gov

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