This study aims at exploring the analgesic efficacy, and safety of Ketamine instillation into the wound of total thyroidectomy compared to placebo,and to systemic ketamine administration (I.M. injection of the same dose) with respect to postoperative VAS, first request of analgesia, total opioid consumption, and with respect to possible side effects.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
90
intra-wound instillation of ketamine (1 mg/ kg) and normal saline in a total volume of 10 ml dispersed evenly throughout the wound; given after hemostasis and before wound closure
intra-wound instillation of normal saline in a total volume of 10 ml dispersed evenly throughout the wound; given after hemostasis and before wound closure
intra-muscular administration of ketamine (1 mg/ kg), given before wound closure.
total opioid consumption
the total amount of morphine consumed during follow up period
Time frame: 24 hours
first request of analgesia
time to first request of rescue analgesic drug
Time frame: 24 hours
VAS
effect of study drugs on postoperative pain measured by VAS score
Time frame: 24 hours
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