Investigate the effects of dexmedetomidine on postoperative cognitive function in patients undergoing shoulder arthroscopy with beach chair position under desflurane anesthesia.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
80
Administration of dexmedetomidine at a rate 0.6 ug/kg/hr during surgery.
Administration of same amount of dexmedetomidine at a rate 0.6 ug/kg/hr during surgery.
Department of Anesthesiology and Pain Medicine, Severance Hospital, Yonsei University College of Medicine
Seoul, South Korea
Number of patients with postoperative cognitive decline assessed by mini-mental state examination
to compare cognitive decline after surgery between control and dexmedetomidine group with mini-mental state examination.
Time frame: from 1 day before surgery to postoperative 1 day
Number of patients with postoperative cognitive decline assessed by a battery of psychometric test
to compare cognitive decline after surgery between control and dexmedetomidine group with a battery of psychometric test. The battery consists of copy geometric form test, two-dimensional model test, grooved pegboard test, colored block design test, puzzle test, clock drawing test.
Time frame: from 1 day before surgery to postoperative 1 day
Number of patients with increase of S100ß protein after surgery assessed by ELISA assay with blood of patients
S100ß protein is the biologic marker for neuroinflammation
Time frame: from 5 min after induction of anesthesia to an 1 hour after surgery
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.