Effect of Different Pre-seasonal BM32 Dosings on the Induction of a Protective Immune Response

Inclusion Criteria: * The subjects are grass pollen allergic but otherwise healthy. Healthy subjects are defined as individuals who are free from clinically significant illness or disease as determined by their medical history (including family), physical examination, laboratory studies, and other tests. * They are aged 18 to 60 years inclusive. * They have a history of seasonal allergic rhinitis (SAR) to grass pollen. * They have a normal electrocardiogram without clinically significant abnormalities. * They exhibit a moderate to severe response to approximately 1500 grass pollen grains/m3 after the first 2h in the Vienna Challenge Chamber, which is defined as a nasal symptom score (TNSS) of at least 6. (Nasal symptom score is the sum of nasal obstruction, rhinorrhoea, itchy nose and sneezing, each of which have been scored on a scale from 0 to 3). * They have a positive skin prick test with a wheal diameter \>5mm for grass pollen extract at the screening visit. * They have a positive serum IgE test for timothy grass pollen and to rPhl p 1+rPhl p 5 at the screening visit (ImmunoCAP ≥3.5 kUA/l; i.e ≥ class 2).. * There are no conditions or factors which would make the subject unlikely to be able to stay in the chamber for 6 hours. * They are capable of giving informed consent which includes compliance with the requirements and restrictions listed in the consent form. * They are available to complete all study measurements Exclusion Criteria: * Sensitization to Phl p 7 * Pregnant, lactating or sexually active women with childbearing potential who are not using a medically accepted birth control method (pregnancy to be controlled by a pregnancy dipstick test). * On examination the subject is found to have any structural nasal abnormalities or nasal polyposis, a history of frequent nosebleeds, recent nasal surgery or ongoing upper respiratory tract infection which in the Responsible Physician's opinion renders the subject unsuitable for participation in the study. * Any respiratory disease other than mild stable asthma that is controlled with occasional use of as-needed short-acting beta-agonists and associated with normal lung function. * The subject is concurrently participating or has participated in any clinical study in the previous month. * Participation in a SIT trial for grass pollen allergy in the three years prior to this study. * Past or present disease, which as judged by the investigator, may affect the outcome of this study. These diseases include, but are not limited to, cardiovascular disease, malignancy, hepatic disease, renal disease, haematological disease, neurological disease, endocrine disease or pulmonary disease (including but not confined to chronic bronchitis, emphysema, bronchiectasis or pulmonary fibrosis).