The purpose of this clinical trial is to investigate the relationship between the gene polymorphism of aldehyde dehydrogenase 2 and contrast induced nephropathy and its mechanism.
Patients undergoing coronary angiography or percutaneous coronary intervention will be recruited in this study after they sign the informed consent.5ml venous blood was extracted from the peripheral vein before the operation to detect the renal function, the genotype and enzyme activity of aldehyde dehydrogenase 2 ,and the levels of oxidative stress and inflammation.Another 5ml venous blood was extracted from the peripheral vein 24-72 hours after the operation to detect the renal function and the levels of oxidative stress and inflammation.Activated oxygen protein products , 4-HNE and hs-CRP as markers for oxidative stress and inflammation.The renal function index contains serum creatinine，urea nitrogen and cystatin C.
Study Type
OBSERVATIONAL
Enrollment
500
Qilu Hospital of Shandong University
Jinan, Shandong, China
RECRUITINGNumber of patients with different ALDH2 genotype
Time frame: 1-30 days after samples collected
Change from baseline renal function after the operation
The baseline of renal function will be tested at the next morning after admission .The renal function will be tested again 24-72 hours after coronary angiography or coronary intervention.The changes of renal function will be recorded.The renal function index contains serum creatinine,urea nitrogen and cystatin C.
Time frame: at admission and 24-72hours after coronary angiography or coronary intervention
Aldehyde dehydrogenase 2 activity
Time frame: 1-30 days after samples collected
Activated oxygen protein products, 4-HNE and hs-CRP
Activated oxygen protein products , 4-HNE and hs-CRP as markers for oxidative stress and inflammation.
Time frame: 1-30 days after samples collected
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