Addition of PegIFN Alfa-2a to CHB Patients Treated With Nucleot(s)Ides

Inclusion Criteria: 1. Male and female subjects,18-65 years 2. positive for hepatitis B surface antigen (HBsAg) and negative for antibodies to HBsAg (anti-HBs antibodies) for at least 6 months before NAs treated 3. nucleot(s)ides monotherapy (including lamivudine, adefovir, entecavir, tenofovir) and achieved HBV DNA\<1000 copies/mL with HBsAg \<3000 IU/mL, positive or negative for HBeAg, and negative for anti-HBs antibodies 4. Subjects with no contra-indications to Peginterferon alfa therapy as detailed in the label (Hypersensitivity to the active substance, to alpha interferon, or to any of the excipients; Autoimmune hepatitis; Severe hepatic dysfunction or decompensated cirrhosis of the liver; A history of severe pre-existing cardiac disease, including unstable or uncontrolled cardiac disease in the previous six months) 5. Subjects who are not co-infected with Hepatitis A Virus, Hepatitis C Virus or HIV 6. Female subjects not pregnant or breast feeding when Peginterferon alfa treatment commenced, and aware of the requirement to use an effective method of contraception during therapy 7. Written informed consent signed. Exclusion Criteria: 1. positive for Hepatitis A Virus Ab, HCV-RNA or positive for Hepatitis C Virus Ab, HDV Ab, HEV Ab or positive for HIV Ab in screening period 2. Hepatocellular carcinoma(HCC) or alpha feto protein(AFP) levels more than 100 ng/ml and Hepatic malignant potential of Imaging examination or AFP levels more than 100 ng/ml for 3 months 3. Compensated or Decompensated liver cirrhosis: with history of cirrhosis before nucleot(s)ides treatment or Child-Pugh score ≥ 5 or Complications of liver cirrhosis such as ascites, hepatic encephalopathy, esophageal gastric varices bleeding 4. Autoimmune disease including Autoimmune hepatitis and Psoriasis and so on 5. Pregnant women and lactating women or patients with pregnancy plans and not willing to use contraception during the study period 6. A history of immunoregulation drug therapy within one year before entry including IFN and so on 7. Have a history of alcohol abuse 8. With severe psychiatric condition or nervous disease such as epilepsy, depression, mania, epilepsy, schizophrenia and so on 9. A neutrophil count of less than 1500 per cubic millimeter or a platelet count of less than 90,000 per cubic millimeter 10. Severe organ dysfunction 11. With other malignant tumors(exclude the cured ones) 12. Uncontrolled diabetes, hypertension or thyroid disease 13. A serum creatinine level that was more than 1.5 times the upper limit of the normal range 14. Hypersensitivity to interferon(IFN) or its active substance, and ineligible to IFN 15. Participate in other clinical studies at the same time 16. Patients unsuitable for the research -