Ischemia-reperfusion (I/R) injury is a prominent cause of delayed graft function(DGF) after kidney transplantation. Reactive oxygen species play a crucial role in I/R injury. Edaravone is a synthetic radical scavenger that has been used in acute stroke. Some animal experiments have revealed its beneficial effects against I/R injury, our goal is therefore to investigate the effectiveness of a recipient pretreatment with Edaravone at reducing the occurrence of DGF after kidney transplantation.
Participants will be randomly assigned, in a 1:1 ratio, to receive Edaravone or control (0.9 %Sodium Chloride Solution,0.9%NaCl). The randomization sequence will be computer-generated, and randomization will be performed in blocks and will be stratified according to participating center.Edaravone and 0.9 %NaCl solution will be treated at 10 minutes before kidney reperfusion, ending in 30 minutes. The number of dialysis and the serum creatinine level within the first week after the transplantation will be recorded. The participation of each patient is scheduled for 1 month.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
150
Edaravone 30mg dissolved in 0.9%NaCl 100ml will be treated at 10 minutes before kidney reperfusion , ending in 30 minutes.The number of dialysis and the serum creatinine level within the first week after the transplantation will be recorded.The participation of each patient is scheduled for 1 month.
100ml 0.9%%NaCl solution,but without edaravone ,will be treated at 10 minutes before kidney reperfusion , ending in 30 minutes. Standard anaesthesia and standard cure are given for all patients. During the operation we maintain the target blood pressure by keeping Central Venous Pressure(CVP)\> 6 mmHg
Incidence of DGF(postoperative complication after kidney transplantation)（%）
Time frame: in the first week after the kidney transplantation
serum creatinine value (umoI/L)
Time frame: within the first week
average daily urinary volume（ml）
Time frame: within the first week
Hospital stays after operation(d)
Time frame: Participants will be followed for the duration of hospital stay, an expected average of 2 weeks
graft survival
Time frame: within 30 days after surgery
other postoperative complication:acute rejection episodes、thrombosis、infections
Time frame: within 30 days after surgery
Content of Malondialdehyde（mol/m l）in the blood
Time frame: before transplantation and 1, 2, 3 days after transplantation
Content of Superoxide dismutase（U /m l) in the blood
Time frame: before transplantation and 1, 2, 3 days after transplantation
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